Effects of gamma interferon and indomethacin in preventing Brucella abortus infections in mice.

نویسندگان

  • M G Stevens
  • G W Pugh
  • L B Tabatabai
چکیده

Increased resistance to infection with Brucella abortus 2308 resulted when recombinant murine gamma interferon (rMuIFN-gamma) was given to mice both before and during infection but not when given only before infection. Mice given rMuIFN-gamma had enhanced peritoneal and splenic macrophage bactericidal activity against B. abortus. Treatment of mice with rMuIFN-gamma plus indomethacin did not further enhance resistance to infection or macrophage bactericidal activity compared with that after treatment of mice with rMuIFN-gamma alone.

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عنوان ژورنال:
  • Infection and immunity

دوره 60 10  شماره 

صفحات  -

تاریخ انتشار 1992